75, 100, and 150 um ID C2 and C4 Columns

We provide high-resolution nanoLC columns for top-down separating proteoforms to achieve maximal coverage of  mass spectrometry analysis of proteoforms (proteome protein isoforms) functioning in a specific biological process.  Our high-resolution nanoLC columns generate separation peak capacities up to 800−1,000 for proteoforms, allowing characterization of >10,000 proteoforms for >1,500 proteins from a one-shot single nanoLC–tandem mass spectrometry analysis. Implementing such high-resolution nanoLC in various platforms of multi-dimensional top-down proteomic analysis can further extend the analysis coverage.